What is Gene Ontology?
Ontology is a logic-based organization structure for knowledge. Gene ontology classifies gene products using three different ontologies: cellular component, molecular function, and biological processes. [1]
Biological processes: represents molecular events or functions. These can include subcellular metabolic pathways, organ and tissue-level chains of events, and organisms-level processes and behaviors. [2]
Molecular function: Represents activities of gene products at molecular level. These include catalysis of reactions or binding or chemicals and molecules. [2]
Cellular component: Represents the location of cellular structures where the gene products perform their functions. These can include both cell subcellular structures and the extracellular environment. [2]
Biological processes: represents molecular events or functions. These can include subcellular metabolic pathways, organ and tissue-level chains of events, and organisms-level processes and behaviors. [2]
Molecular function: Represents activities of gene products at molecular level. These include catalysis of reactions or binding or chemicals and molecules. [2]
Cellular component: Represents the location of cellular structures where the gene products perform their functions. These can include both cell subcellular structures and the extracellular environment. [2]
Gene Ontology of SGSH
Discussion
The cellular, molecular and biological levels of gene ontology illustrate that SGSH is involved in enzyme regulation and catabolism process. As the cellular ontology indicates, the involvement of lysosomes make sense as SGSH mutation causes a lysosomal storage disorder (Sanfilippo syndrome). Catabolic processes of heparan sulfate proteoglycan is the clear biological process ontology. Brain development and neuronal function, however, is the less obvious link between SGSH and its biological process ontology.
References
Header: https://www.researchgate.net/figure/Network-of-political-blogs-during-the-2004-US-presidential-election-Democratic-and_fig1_327159933
[1] http://geneontology.org/docs/ontology-documentation/
[2] https://www.ebi.ac.uk/training/online/course/goa-and-quickgo-quick-tour/what-go
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
[1] http://geneontology.org/docs/ontology-documentation/
[2] https://www.ebi.ac.uk/training/online/course/goa-and-quickgo-quick-tour/what-go
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.