What is Chemical Genomics?
Chemical genomics refers to the study of how small molecules interact within the cells. The application of chemical genomics includes experiments of drug treatments and large-scale protein analysis. Chemical genomics provides a way to study gene and protein functions and gives insight into finding new treatment and therapies. [1]
Chemical genomic screen in mice
In vitro chemical genomic screen using mice can be use to identify small molecules rescuing the phenotypes resulting from SGSH mutant mice. To do this, I would prepare neuronal cell cultures using the mouse models. Then I would use a diverse chemical library and look for positive hits, to identify molecules that can rescue the phenotypes, such as the GAGs accumulation in the lysosomes of neurons.
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Discussion
Although SGSH is not directly linked with a molecule or drug, a chemical genomics screen discussed above could potentially result in a target for drug therapies.
References
Header adapted from: https://www.trypanosomatics.org/project/chemogenomics/
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138939/
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138939/
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.